The Skydrive integration with Office 2013 is really nice. But what about Office 365? If you try opening a document from your portal, you get an error saying that the correct version of Word is not installed.
But what you can do is just add your portal as a location in Word etc.
Click on Add a place, then Office365, and enter your credentials. You can then browse your document libraries from with Word, or other office 2013 apps.